Ontology highlight
ABSTRACT:
SUBMITTER: Yu CH
PROVIDER: S-EPMC3919603 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Nucleic acids research 20131030 3
Guanine-rich sequences can fold into four-stranded structures of stacked guanine-tetrads, so-called G-quadruplexes (G4). These unique motifs have been extensively studied on the DNA level; however, exploration of the biological roles of G4s at the RNA level is just emerging. Here we show that G4 RNA when introduced within coding regions are capable of stimulating -1 ribosomal frameshifting (-1 FS) in vitro and in cultured cells. Systematic manipulation of the loop length between each G-tract rev ...[more]