The genomic landscape of hypodiploid acute lymphoblastic leukemia.
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ABSTRACT:
SUBMITTER: Holmfeldt L
PROVIDER: S-EPMC3919793 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Publications
The genomic landscape of hypodiploid acute lymphoblastic leukemia.
Holmfeldt Linda L Wei Lei L Diaz-Flores Ernesto E Walsh Michael M Zhang Jinghui J Ding Li L Payne-Turner Debbie D Churchman Michelle M Andersson Anna A Chen Shann-Ching SC McCastlain Kelly K Becksfort Jared J Ma Jing J Wu Gang G Patel Samir N SN Heatley Susan L SL Phillips Letha A LA Song Guangchun G Easton John J Parker Matthew M Chen Xiang X Rusch Michael M Boggs Kristy K Vadodaria Bhavin B Hedlund Erin E Drenberg Christina C Baker Sharyn S Pei Deqing D Cheng Cheng C Huether Robert R Lu Charles C Fulton Robert S RS Fulton Lucinda L LL Tabib Yashodhan Y Dooling David J DJ Ochoa Kerri K Minden Mark M Lewis Ian D ID To L Bik LB Marlton Paula P Roberts Andrew W AW Raca Gordana G Stock Wendy W Neale Geoffrey G Drexler Hans G HG Dickins Ross A RA Ellison David W DW Shurtleff Sheila A SA Pui Ching-Hon CH Ribeiro Raul C RC Devidas Meenakshi M Carroll Andrew J AJ Heerema Nyla A NA Wood Brent B Borowitz Michael J MJ Gastier-Foster Julie M JM Raimondi Susana C SC Mardis Elaine R ER Wilson Richard K RK Downing James R JR Hunger Stephen P SP Loh Mignon L ML Mullighan Charles G CG
Nature genetics 20130120 3
The genetic basis of hypodiploid acute lymphoblastic leukemia (ALL), a subtype of ALL characterized by aneuploidy and poor outcome, is unknown. Genomic profiling of 124 hypodiploid ALL cases, including whole-genome and exome sequencing of 40 cases, identified two subtypes that differ in the severity of aneuploidy, transcriptional profiles and submicroscopic genetic alterations. Near-haploid ALL with 24-31 chromosomes harbor alterations targeting receptor tyrosine kinase signaling and Ras signali ...[more]
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