Characterisation of the genomic landscape of CRLF2-rearranged acute lymphoblastic leukemia.
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ABSTRACT:
SUBMITTER: Russell LJ
PROVIDER: S-EPMC5396319 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Publications
Characterisation of the genomic landscape of CRLF2-rearranged acute lymphoblastic leukemia.
Russell Lisa J LJ Jones Lisa L Enshaei Amir A Tonin Stefano S Ryan Sarra L SL Eswaran Jeyanthy J Nakjang Sirintra S Papaemmanuil Elli E Tubio Jose M C JM Fielding Adele K AK Vora Ajay A Campbell Peter J PJ Moorman Anthony V AV Harrison Christine J CJ
Genes, chromosomes & cancer 20170118 5
Deregulated expression of the type I cytokine receptor, CRLF2, is observed in 5-15% of precursor B-cell acute lymphoblastic leukaemia (B-ALL). We aimed to determine the clinical and genetic landscape of those with IGH-CRLF2 or P2RY8-CRLF2 (CRLF2-r) using multiple genomic approaches. Clinical and demographic features of CRLF2-r patients were characteristic of B-ALL. Patients with IGH-CRLF2 were older (14 y vs. 4 y, P < .001), while the incidence of CRLF2-r among Down syndrome patients was high (5 ...[more]
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