Hypoxia induces re-entry of committed cells into pluripotency.
Ontology highlight
ABSTRACT:
SUBMITTER: Mathieu J
PROVIDER: S-EPMC3921075 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Publications
Hypoxia induces re-entry of committed cells into pluripotency.
Mathieu Julie J Zhang Zhan Z Nelson Angelique A Lamba Deepak A DA Reh Thomas A TA Ware Carol C Ruohola-Baker Hannele H
Stem cells (Dayton, Ohio) 20130901 9
Adult stem cells reside in hypoxic niches, and embryonic stem cells (ESCs) are derived from a low oxygen environment. However, it is not clear whether hypoxia is critical for stem cell fate since for example human ESCs (hESCs) are able to self-renew in atmospheric oxygen concentrations as well. We now show that hypoxia can govern cell fate decisions since hypoxia alone can revert hESC- or iPSC-derived differentiated cells back to a stem cell-like state, as evidenced by re-activation of an Oct4-p ...[more]
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