Stem cells resume asymmetric division upon niche re-entry

ABSTRACT: Tissue homeostasis and repair relies on a stable stem cell pool and deficiencies in stem cells contribute to aging associated effects and pathologies. In the Drosophila testis, a pool of germline stem cells (GSCs) is established through asymmetric division, where one daughter cell remains within the niche for self-renewal and the other daughter cell is placed outside the niche for differentiation. However, GSCs are lost at a regular frequency at steady state from the niche, thus requiring mechanism to continually replenish the stem cell pool. In this study, we perform long-term live imaging of the testis and show that the dedifferentiation of differentiating cells is the predominant mechanism of niche replenishment. These dedifferentiating cells arrest in late G2 via the centrosome orienta

ORGANISM(S): Drosophila melanogaster (fruit fly)

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PROVIDER: S-BSST1748 | biostudies-other |

REPOSITORIES: biostudies-other