Ontology highlight
ABSTRACT:
SUBMITTER: Dierkes R
PROVIDER: S-EPMC3921225 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Dierkes Rüdiger R Warnking Kathrin K Liedmann Swantje S Seyer Roman R Ludwig Stephan S Ehrhardt Christina C
PloS one 20140211 2
The frequent emergence of new influenza viruses in the human population underlines the urgent need for antiviral therapeutics in addition to the preventative vaccination against the seasonal flu. To circumvent the development of resistance, recent antiviral approaches target cellular proteins needed by the virus for efficient replication. We investigated the contribution of the small GTPase Rac1 to the replication of influenza viruses. Inhibition of Rac1 by NSC23766 resulted in impaired replicat ...[more]