Ontology highlight
ABSTRACT:
SUBMITTER: Katsuki M
PROVIDER: S-EPMC3921467 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Katsuki Miho M Drummond Douglas R DR Cross Robert A RA
Nature communications 20140101
Natural microtubules typically include one A-lattice seam within an otherwise helically symmetric B-lattice tube. It is currently unclear how A-lattice seams influence microtubule dynamic instability. Here we find that including extra A-lattice seams in GMPCPP microtubules, structural analogues of the GTP caps of dynamic microtubules, destabilizes them, enhancing their median shrinkage rate by >20-fold. Dynamic microtubules nucleated by seeds containing extra A-lattice seams have growth rates si ...[more]