Ontology highlight
ABSTRACT:
SUBMITTER: Ko YG
PROVIDER: S-EPMC3921693 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Ko Young-Gwang YG Co Carlos C CC Ho Chia-Chi CC
Soft matter 20130201 8
Directing cell movements within 3D channels is a key challenge in biomedical devices and tissue engineering. In two dimensions, closely spaced arrays of asymmetric teardrop islands can intermittently polarize cells and sustain their autonomous directional migration with no gradients. However, in 3D microchannels composed of linearly connected teardrop segments, negligibly low directional bias is observed. Rather than adopt teardrop shapes, cells evade morphological polarization by spreading acro ...[more]