Ontology highlight
ABSTRACT:
SUBMITTER: Nakajima A
PROVIDER: S-EPMC4272253 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Nakajima Akihiko A Ishihara Shuji S Imoto Daisuke D Sawai Satoshi S
Nature communications 20141106
How spatial and temporal information are integrated to determine the direction of cell migration remains poorly understood. Here, by precise microfluidics emulation of dynamic chemoattractant waves, we demonstrate that, in Dictyostelium, directional movement as well as activation of small guanosine triphosphatase Ras at the leading edge is suppressed when the chemoattractant concentration is decreasing over time. This 'rectification' of directional sensing occurs only at an intermediate range of ...[more]