Ontology highlight
ABSTRACT:
SUBMITTER: Curti BD
PROVIDER: S-EPMC3922072 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Curti Brendan D BD Kovacsovics-Bankowski Magdalena M Morris Nicholas N Walker Edwin E Chisholm Lana L Floyd Kevin K Walker Joshua J Gonzalez Iliana I Meeuwsen Tanisha T Fox Bernard A BA Moudgil Tarsem T Miller William W Haley Daniel D Coffey Todd T Fisher Brenda B Delanty-Miller Laurie L Rymarchyk Nicole N Kelly Tracy T Crocenzi Todd T Bernstein Eric E Sanborn Rachel R Urba Walter J WJ Weinberg Andrew D AD
Cancer research 20131031 24
OX40 is a potent costimulatory receptor that can potentiate T-cell receptor signaling on the surface of T lymphocytes, leading to their activation by a specifically recognized antigen. In particular, OX40 engagement by ligands present on dendritic cells dramatically increases the proliferation, effector function, and survival of T cells. Preclinical studies have shown that OX40 agonists increase antitumor immunity and improve tumor-free survival. In this study, we performed a phase I clinical tr ...[more]