Unknown

Dataset Information

0

Characterization of CYP76AH4 clarifies phenolic diterpenoid biosynthesis in the Lamiaceae.


ABSTRACT: Miltiradiene (1) is the precursor of phenolic diterpenoids such as ferruginol (2), requiring aromatization and hydroxylation. While this has been attributed to a single cytochrome P450 (CYP76AH1), characterization of the rosemary ortholog CYP76AH4 led to the discovery that these CYPs simply hydroxylate the facilely oxidized aromatic intermediate abietatriene (3).

SUBMITTER: Zi J 

PROVIDER: S-EPMC3922537 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

altmetric image

Publications

Characterization of CYP76AH4 clarifies phenolic diterpenoid biosynthesis in the Lamiaceae.

Zi Jiachen J   Peters Reuben J RJ  

Organic & biomolecular chemistry 20131010 44


Miltiradiene (1) is the precursor of phenolic diterpenoids such as ferruginol (2), requiring aromatization and hydroxylation. While this has been attributed to a single cytochrome P450 (CYP76AH1), characterization of the rosemary ortholog CYP76AH4 led to the discovery that these CYPs simply hydroxylate the facilely oxidized aromatic intermediate abietatriene (3). ...[more]

Similar Datasets

| S-EPMC8306933 | biostudies-literature
| S-EPMC4360168 | biostudies-literature
| S-EPMC6100036 | biostudies-literature
| S-EPMC4277783 | biostudies-literature
| S-EPMC9247737 | biostudies-literature
| PRJNA311935 | ENA
| S-EPMC5330306 | biostudies-literature
| S-EPMC5118073 | biostudies-literature
| S-EPMC4364678 | biostudies-literature
| S-EPMC5617736 | biostudies-literature