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Characterization of CYP76AH4 clarifies phenolic diterpenoid biosynthesis in the Lamiaceae.


ABSTRACT: Miltiradiene (1) is the precursor of phenolic diterpenoids such as ferruginol (2), requiring aromatization and hydroxylation. While this has been attributed to a single cytochrome P450 (CYP76AH1), characterization of the rosemary ortholog CYP76AH4 led to the discovery that these CYPs simply hydroxylate the facilely oxidized aromatic intermediate abietatriene (3).

SUBMITTER: Zi J 

PROVIDER: S-EPMC3922537 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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Characterization of CYP76AH4 clarifies phenolic diterpenoid biosynthesis in the Lamiaceae.

Zi Jiachen J   Peters Reuben J RJ  

Organic & biomolecular chemistry 20131010 44


Miltiradiene (1) is the precursor of phenolic diterpenoids such as ferruginol (2), requiring aromatization and hydroxylation. While this has been attributed to a single cytochrome P450 (CYP76AH1), characterization of the rosemary ortholog CYP76AH4 led to the discovery that these CYPs simply hydroxylate the facilely oxidized aromatic intermediate abietatriene (3). ...[more]

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