Ontology highlight
ABSTRACT:
SUBMITTER: Zi J
PROVIDER: S-EPMC3922537 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Zi Jiachen J Peters Reuben J RJ
Organic & biomolecular chemistry 20131010 44
Miltiradiene (1) is the precursor of phenolic diterpenoids such as ferruginol (2), requiring aromatization and hydroxylation. While this has been attributed to a single cytochrome P450 (CYP76AH1), characterization of the rosemary ortholog CYP76AH4 led to the discovery that these CYPs simply hydroxylate the facilely oxidized aromatic intermediate abietatriene (3). ...[more]