Ontology highlight
ABSTRACT:
SUBMITTER: Radtke J
PROVIDER: S-EPMC3922606 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Radtke Juliane J Geissler Stefanie S Schutkowski Alexandra A Brandsch Corinna C Kluge Holger H Duranti Marcello M MM Keller Sylvia S Jahreis Gerhard G Hirche Frank F Stangl Gabriele I GI
Nutrition & metabolism 20140203 1
<h4>Background</h4>Lupin proteins exert hypocholesterolemic effects in man and animals, although the underlying mechanism remains uncertain. Herein we investigated whether lupin proteins compared to casein modulate sterol excretion and mRNA expression of intestinal sterol transporters by use of pigs as an animal model with similar lipid metabolism as humans, and cellular cholesterol-uptake by Caco-2 cells.<h4>Methods</h4>Two groups of pigs were fed cholesterol-containing diets with either 230 g/ ...[more]