Ontology highlight
ABSTRACT:
SUBMITTER: Filbin MG
PROVIDER: S-EPMC3923315 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Nature medicine 20130929 11
In glioblastoma, phosphatidylinositol 3-kinase (PI3K) signaling is frequently activated by loss of the tumor suppressor phosphatase and tensin homolog (PTEN). However, it is not known whether inhibiting PI3K represents a selective and effective approach for treatment. We interrogated large databases and found that sonic hedgehog (SHH) signaling is activated in PTEN-deficient glioblastoma. We demonstrate that the SHH and PI3K pathways synergize to promote tumor growth and viability in human PTEN- ...[more]