Ontology highlight
ABSTRACT:
SUBMITTER: Shin YJ
PROVIDER: S-EPMC6504209 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Shin Yong Jae YJ Sa Jason K JK Lee Yeri Y Kim Donggeon D Chang Nakho N Cho Hee Jin HJ Son Miseol M Oh Michael Y T MYT Shin Kayoung K Lee Jin-Ku JK Park Jiwon J Jo Yoon Kyung YK Kim Misuk M Paddison Patrick J PJ Tergaonkar Vinay V Lee Jeongwu J Nam Do-Hyun DH
The Journal of experimental medicine 20190321 5
Glioblastoma <b>(</b>GBM<b>)</b> is the most malignant brain tumor with profound genomic alterations. Tumor suppressor genes regulate multiple signaling networks that restrict cellular proliferation and present barriers to malignant transformation. While bona fide tumor suppressors such as <i>PTEN</i> and <i>TP53</i> often undergo inactivation due to mutations, there are several genes for which genomic deletion is the primary route for tumor progression. To functionally identify putative tumor s ...[more]