Myristicyclins A and B: antimalarial procyanidins from Horsfieldia spicata from Papua New Guinea.
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ABSTRACT:
SUBMITTER: Lu Z
PROVIDER: S-EPMC3923365 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
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Myristicyclins A and B: antimalarial procyanidins from Horsfieldia spicata from Papua New Guinea.
Lu Zhenyu Z Van Wagoner Ryan M RM Pond Cristopher D CD Pole Ann R AR Jensen James B JB Blankenship D'Arbra D Grimberg Brian T BT Kiapranis Robert R Matainaho Teatulohi K TK Barrows Louis R LR Ireland Chris M CM
Organic letters 20131219 2
An antimalarial screen for plants collected from Papua New Guinea identified an extract of Horsfieldia spicata as having activity. Isolation of the active constituents led to the identification of two new compounds: myristicyclins A (1) and B (2). Both compounds are procyanidin-like congeners of myristinins lacking a pendant aromatic ring. Myristicyclin A was found to inhibit the ring, trophozoite, and schizont stages of Plasmodium falciparum at similar concentrations in the mid-μM range. ...[more]
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