Ontology highlight
ABSTRACT:
SUBMITTER: Dilworth JT
PROVIDER: S-EPMC3923431 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Dilworth Joshua T JT Wojtkowiak Jonathan W JW Mathieu Patricia P Tainsky Michael A MA Reiners John J JJ Mattingly Raymond R RR Hancock Chad N CN
Cancer biology & therapy 20081207 12
Neurofibromatosis Type 1 (NF1) is characterized by the abnormal proliferation of neuroectodermal tissues and the development of certain tumors, particularly neurofibromas, which may progress into malignant peripheral nerve sheath tumors (MPNSTs). Effective pharmacological therapy for the treatment of NF1 tumors is currently unavailable and the prognosis for patients with MPNSTs is poor. Loss of neurofibromin correlates with increased expression of the epidermal growth factor receptor (EGFR) and ...[more]