Ontology highlight
ABSTRACT:
SUBMITTER: Klementiev B
PROVIDER: S-EPMC3923439 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Klementiev Boris B Li Shizhong S Korshunova Irina I Dmytriyeva Oksana O Pankratova Stanislava S Walmod Peter S PS Kjær Laura K LK Dahllöf Mattias S MS Lundh Morten M Christensen Dan P DP Mandrup-Poulsen Thomas T Bock Elisabeth E Berezin Vladimir V
Journal of neuroinflammation 20140203
<h4>Background</h4>Interleukin 1 (IL-1) is implicated in neuroinflammation, an essential component of neurodegeneration. We evaluated the potential anti-inflammatory effect of a novel peptide antagonist of IL-1 signaling, Ilantide.<h4>Methods</h4>We investigated the binding of Ilantide to IL-1 receptor type I (IL-1RI) using surface plasmon resonance, the inhibition of Il-1β-induced activation of nuclear factor κB (NF-κB) in HEK-Blue cells that contained an IL-1β-sensitive reporter, the secretion ...[more]