Ontology highlight
ABSTRACT:
SUBMITTER: Herder C
PROVIDER: S-EPMC2646020 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Herder Christian C Brunner Eric J EJ Rathmann Wolfgang W Strassburger Klaus K Tabák Adam G AG Schloot Nanette C NC Witte Daniel R DR
Diabetes care 20081210 3
<h4>Objective</h4>Interleukin-1 receptor antagonist (IL-1Ra), a natural inhibitor of interleukin-1 beta, has been shown to improve beta-cell function and glycemic control in patients with type 2 diabetes. The aim of this study was to investigate whether baseline systemic levels of IL-1Ra are associated with incident type 2 diabetes during more than 10 years of follow-up.<h4>Research design and methods</h4>We measured serum IL-1Ra concentrations in a nested case-control study (181 case and 376 ag ...[more]