Ontology highlight
ABSTRACT:
SUBMITTER: Sanchez-Solana B
PROVIDER: S-EPMC3923981 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Sánchez-Solana Beatriz B Li Da-Qiang DQ Kumar Rakesh R
Biochimica et biophysica acta 20131125 2
Microrchidia (MORC) family CW-type zinc finger 2 (MORC2) has been shown to be involved in several nuclear processes, including transcription modulation and DNA damage repair. However, its cytosolic function remains largely unknown. Here, we report an interaction between MORC2 and adenosine triphosphate (ATP)-citrate lyase (ACLY), an enzyme that catalyzes the formation of acetyl-coA and plays a central role in lipogenesis, cholesterogenesis, and histone acetylation. Furthermore, we demonstrate th ...[more]