Ontology highlight
ABSTRACT:
SUBMITTER: Wang G
PROVIDER: S-EPMC4496403 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Wang Guiling G Song Yanyan Y Liu Tong T Wang Chunyu C Zhang Qing Q Liu Furong F Cai Xinze X Miao Zhifeng Z Xu Hongde H Xu Huimian H Cao Liu L Li Feng F
Oncotarget 20150101 12
To date, microrchidia (MORC) family CW-type zinc-finger 2 (MORC2), has been found to be involved in p21-activated kinase1 (PAK1) pathway to maintain genomic integrity. Here, we explore its novel role in cancer. We demonstrate that PAK1-mediated MORC2 phosphorylation promotes cell cycle progression, defective phosphorylation of MORC2-S677A results in attenuated cell proliferation and tumorigenicity of gastric cancer cells, which is significantly enhanced in overexpression of phospho-mimic MORC2-S ...[more]