Enantioselective, nickel-catalyzed Suzuki cross-coupling of quinolinium ions.

ABSTRACT: Quinolinium ions are engaged in an asymmetric, Ni-catalyzed Suzuki cross-coupling to yield 2-aryl- and 2-heteroaryl-1,2-dihydroquinolines. Key to the development of this method is the use of a Ni(II) precatalyst that activates without the need for strong reductants or high temperatures. The Ni-iminium activation mode is demonstrated as an exceptionally mild pathway to generate enantioenriched products from racemic starting materials.

SUBMITTER: Shields JD 

PROVIDER: S-EPMC3924560 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature