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Identification of a major locus interacting with MC1R and modifying black coat color in an F? Nellore-Angus population.

ABSTRACT: BACKGROUND: In cattle, base color is assumed to depend on the enzymatic activity specified by the MC1R locus, i.e. the extension locus, with alleles coding for black (E(D)), red (e), and wild-type (E+). In most mammals, these alleles are presumed to follow the dominance model of E(D)?>?E+?>?e, although exceptions are found. In Bos indicus x Bos taurus F2 cattle, some E(D)E+ heterozygotes are discordant with the dominance series for MC1R and display various degrees of red pigmentation on an otherwise predicted black background. The objective of this study was to identify loci that modify black coat color in these individuals. RESULTS: Reddening was classified with a subjective scoring system. Interval analyses identified chromosome-wide suggestive (P?

SUBMITTER: Hanna LL

PROVIDER: S-EPMC3924621 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Identification of a major locus interacting with MC1R and modifying black coat color in an F₂ Nellore-Angus population.

Hanna Lauren L Hulsman LL Sanders James O JO Riley David G DG Abbey Colette A CA Gill Clare A CA

Genetics, selection, evolution : GSE 20140124

<h4>Background</h4>In cattle, base color is assumed to depend on the enzymatic activity specified by the MC1R locus, i.e. the extension locus, with alleles coding for black (E(D)), red (e), and wild-type (E+). In most mammals, these alleles are presumed to follow the dominance model of E(D) > E+ > e, although exceptions are found. In Bos indicus x Bos taurus F2 cattle, some E(D)E+ heterozygotes are discordant with the dominance series for MC1R and display various degrees of red pigmentation on a ...[more]

PMID: 24460986

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