Ontology highlight
ABSTRACT:
SUBMITTER: Zhong H
PROVIDER: S-EPMC9499681 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Zhong Haiwen H Zhang Jian J Tan Cheng C Shi Junsong J Yang Jie J Cai Gengyuan G Wu Zhenfang Z Yang Huaqiang H
International journal of molecular sciences 20220908 18
Black coat color in pigs is determined by the dominant <i>E</i> allele at the <i>MC1R</i> locus. Through comparing <i>MC1R</i> gene sequences between recessive <i>e</i> and dominant <i>E<sup>D1</sup></i> alleles, we identified four missense mutations that could affect MC1R protein function for eumelanin synthesis. With the aim of devising a genetic modification method for pig coat color manipulation, we mutated the <i>e</i> allele in the Duroc breed to the dominant <i>E<sup>D1</sup></i> allele u ...[more]