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Protein coronas suppress the hemolytic activity of hydrophilic and hydrophobic nanoparticles.


ABSTRACT: The role of nanoparticle surface hydrophobicity on its hemolytic property is established in the absence and the presence of plasma proteins. Significantly, the formation of plasma protein corona on NP surface protects red blood cells from both hydrophilic and hydrophobic NP-mediated hemolysis.

SUBMITTER: Saha K 

PROVIDER: S-EPMC3924723 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

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Protein coronas suppress the hemolytic activity of hydrophilic and hydrophobic nanoparticles.

Saha Krishnendu K   Moyano Daniel F DF   Rotello Vincent M VM  

Materials horizons 20140101 1


The role of nanoparticle surface hydrophobicity on its hemolytic property is established in the absence and the presence of plasma proteins. Significantly, the formation of plasma protein corona on NP surface protects red blood cells from both hydrophilic and hydrophobic NP-mediated hemolysis. ...[more]

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