Ontology highlight
ABSTRACT:
SUBMITTER: Lin J
PROVIDER: S-EPMC3925658 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Lin JianMin J Spidel Jared L JL Maddage Christopher J CJ Rybinski Katherine A KA Kennedy Rina P RP Krauthauser Candice L M CL Park Young Chul YC Albone Earl F EF Jacob Sara S Goserud Matthew T MT Martinez Bryon P BP Chao Qimin Q Zhou Yuhong Y Nicolaides Nicholas C NC Kline J Bradford JB Grasso Luigi L
Cancer biology & therapy 20130828 11
Because of its high mortality rate, ovarian cancer is a leading cause of death among women and a highly unmet medical need. New therapeutic agents that are effective and well tolerated are needed and cancer antigen-specific monoclonal antibodies that have direct pharmacologic effects or can stimulate immunological responses represent a promising class of agents for the treatment of this disease. The human folate receptor α (FOLR1), which is overexpressed in ovarian cancer but largely absent in n ...[more]