Ontology highlight
ABSTRACT:
SUBMITTER: Yang Z
PROVIDER: S-EPMC6251304 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Yang Zheng Z Liu Xi X Sun Zehua Z Li Jingjing J Tan Weiguo W Yu Weiye W Zhang Meiyun M
Frontiers in immunology 20181116
Antibody-Dependent Cellular Cytotoxicity (ADCC) is a major mechanism of protection against viral infections <i>in vivo</i>. Identification of HIV-1-specific monoclonal antibodies (mAbs) with potent ADCC activity may help develop an effective HIV-1 vaccine. In present study, we isolated such human mAb, designated E10, from an HIV-1-infected patient sample by single B cell sorting and single cell PCR. E10 bound to gp140 trimer and linear peptides derived from gp41 membrane proximal external region ...[more]