Ontology highlight
ABSTRACT:
SUBMITTER: Hiraoka Y
PROVIDER: S-EPMC3926010 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Nature communications 20140101
Body temperature homoeostasis in mammals is governed centrally through the regulation of shivering and non-shivering thermogenesis and cutaneous vasomotion. Non-shivering thermogenesis in brown adipose tissue (BAT) is mediated by sympathetic activation, followed by PGC-1α induction, which drives UCP1. Here we identify nardilysin (Nrd1 and NRDc) as a critical regulator of body temperature homoeostasis. Nrd1(-/-) mice show increased energy expenditure owing to enhanced BAT thermogenesis and hypera ...[more]