Ontology highlight
ABSTRACT:
SUBMITTER: Beguin C
PROVIDER: S-EPMC3926198 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry letters 20111207 2
The kappa opioid receptor (KOPR) has been identified as a potential drug target to prevent or alter the course of mood, anxiety and addictive disorders or reduce response to stress. In a search for highly potent and selective KOPR partial agonists as pharmacological tools, we have modified 12-epi-salvinorin A, a compound which we have previously observed to be a KOPR partial agonist. Five analogues of 12-epi-salvinorin A were synthesized and their effects on G protein activation as well as β-arr ...[more]