Ontology highlight
ABSTRACT:
SUBMITTER: Roach JJ
PROVIDER: S-EPMC5912166 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry letters 20180312 9
The plant metabolite salvinorin A potently and selectively agonizes the human kappa-opioid receptor, an emerging target for next-generation analgesics. Here we review analogs of the salvinorin chemotype and their effects on selectivity, affinity and potency. Extensive peripheral modifications using isolated salvinorin A have delivered a trove of SAR information. More deep-seated changes are now possible by advances in chemical synthesis. ...[more]