Pharmacogenomics of endocrine therapy in breast cancer.
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ABSTRACT:
SUBMITTER: Ingle JN
PROVIDER: S-EPMC3926210 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Publications
Pharmacogenomics of endocrine therapy in breast cancer.
Journal of human genetics 20130502 6
The most important modality of treatment in the two-thirds of patients with an estrogen receptor (ER)-positive early breast cancer is endocrine therapy. In postmenopausal women, options include the selective ER modulators (SERMs), tamoxifen and raloxifene, and the 'third-generation' aromatase inhibitors (AIs), anastrozole, exemestane and letrozole. Under the auspices of the National Institutes of Health Global Alliance for Pharmacogenomics, Japan, the Mayo Clinic Pharmacogenomics Research Networ ...[more]
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