The immunomodulatory effects of endocrine therapy in breast cancer.
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ABSTRACT:
SUBMITTER: Huang H
PROVIDER: S-EPMC7792133 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
The immunomodulatory effects of endocrine therapy in breast cancer.
Huang Huanhuan H Zhou Jun J Chen Hailong H Li Jiaxin J Zhang Chao C Jiang Xia X Ni Chao C
Journal of experimental & clinical cancer research : CR 20210107 1
Endocrine therapies with SERMs (selective estrogen receptor modulators) or SERDs (selective estrogen receptor downregulators) are standard therapies for patients with estrogen receptor (ER)-positive breast cancer. Multiple small molecule inhibitors targeting the PI3K-AKT-mTOR pathway or CDK4/6 have been developed to be used in combination with anti-estrogen drugs to overcome endocrine resistance. In addition to their direct antitumor effects, accumulating evidence has revealed the tumor immune m ...[more]
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