Inhibiting the HIV integration process: past, present, and the future.
Ontology highlight
ABSTRACT:
SUBMITTER: Di Santo R
PROVIDER: S-EPMC3926363 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Publications
Inhibiting the HIV integration process: past, present, and the future.
Journal of medicinal chemistry 20130925 3
HIV integrase (IN) catalyzes the insertion into the genome of the infected human cell of viral DNA produced by the retrotranscription process. The discovery of raltegravir validated the existence of the IN, which is a new target in the field of anti-HIV drug research. The mechanism of catalysis of IN is depicted, and the characteristics of the inhibitors of the catalytic site of this viral enzyme are reported. The role played by the resistance is elucidated, as well as the possibility of bypassi ...[more]
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