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Synthesis of a photocaged tamoxifen for light-dependent activation of Cre-ER recombinase-driven gene modification.


ABSTRACT: We report the design of a water-soluble, quaternized tamoxifen photoprobe and demonstrate its application in light-controlled induction of green fluorescent protein expression via a Cre-ER recombinase system.

SUBMITTER: Inlay MA 

PROVIDER: S-EPMC3926663 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature

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Synthesis of a photocaged tamoxifen for light-dependent activation of Cre-ER recombinase-driven gene modification.

Inlay Matthew A MA   Choe Veronica V   Bharathi Sophia S   Fernhoff Nathaniel B NB   Baker James R JR   Weissman Irving L IL   Choi Seok Ki SK  

Chemical communications (Cambridge, England) 20130501 43


We report the design of a water-soluble, quaternized tamoxifen photoprobe and demonstrate its application in light-controlled induction of green fluorescent protein expression via a Cre-ER recombinase system. ...[more]

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