Ontology highlight
ABSTRACT:
SUBMITTER: Burchacka E
PROVIDER: S-EPMC3926743 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Protein science : a publication of the Protein Society 20131224 2
Staphylococcus aureus is responsible for a variety of human infections, including life-threatening, systemic conditions. Secreted proteome, including a range of proteases, constitutes the major virulence factor of the bacterium. However, the functions of individual enzymes, in particular SplA protease, remain poorly characterized. Here, we report development of specific inhibitors of SplA protease. The design, synthesis, and activity of a series of α-aminoalkylphosphonate diaryl esters and their ...[more]