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Phenotypic and functional characteristic of a newly identified CD8+ Foxp3- CD103+ regulatory T cells.

ABSTRACT: TGF-? and Foxp3 expressions are crucial for the induction and functional activity of CD4(+)Foxp3(+) regulatory T (iTreg) cells. Here, we demonstrate that although TGF-?-primed CD8(+) cells display much lower Foxp3 expression, their suppressive capacity is equivalent to that of CD4(+) iTreg cells, and both Foxp3(-) and Foxp3(+) CD8+ subsets have suppressive activities in vitro and in vivo. CD8(+)Foxp3(-) iTreg cells produce little IFN-? but almost no IL-2, and display a typical anergic phenotype. Among phenotypic markers expressed in CD8(+)Foxp3(-) cells, we identify CD103 expression particularly crucial for the generation and function of this subset. Moreover, IL-10 and TGF-? signals rather than cytotoxicity mediate the suppressive effect of this novel Treg population. Therefore, TGF-? can induce both CD8(+)Foxp3(-) and CD8(+)Foxp3(+) iTreg subsets, which may represent the unique immunoregulatory means to treat autoimmune and inflammatory diseases.

SUBMITTER: Liu Y 

PROVIDER: S-EPMC3927769 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

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Phenotypic and functional characteristic of a newly identified CD8+ Foxp3- CD103+ regulatory T cells.

Liu Ya Y   Lan Qin Q   Lu Ling L   Chen Maogen M   Xia Zanxian Z   Ma Jilin J   Wang Julie J   Fan Huimin H   Shen Yi Y   Ryffel Bernhard B   Brand David D   Quismorio Francisco F   Liu Zhongmin Z   Horwitz David A DA   Xu Anping A   Zheng Song Guo SG  

Journal of molecular cell biology 20130715 1

TGF-β and Foxp3 expressions are crucial for the induction and functional activity of CD4(+)Foxp3(+) regulatory T (iTreg) cells. Here, we demonstrate that although TGF-β-primed CD8(+) cells display much lower Foxp3 expression, their suppressive capacity is equivalent to that of CD4(+) iTreg cells, and both Foxp3(-) and Foxp3(+) CD8+ subsets have suppressive activities in vitro and in vivo. CD8(+)Foxp3(-) iTreg cells produce little IFN-γ but almost no IL-2, and display a typical anergic phenotype.  ...[more]

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