Ontology highlight
ABSTRACT:
SUBMITTER: Wagner JM
PROVIDER: S-EPMC3927790 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Wagner Jonathan M JM Evans Timothy J TJ Korotkov Konstantin V KV
Proteins 20130831 1
EccA1 is an important component of the type VII secretion system (T7SS) that is responsible for transport of virulence factors in pathogenic mycobacteria. EccA1 has an N-terminal domain of unknown function and a C-terminal AAA+ (ATPases associated with various cellular activities) domain. Here we report the crystal structure of the N-terminal domain of EccA1 from Mycobacterium tuberculosis, which shows an arrangement of six tetratricopeptide repeats that may mediate interactions of EccA1 with se ...[more]