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Condensins and 3D Organization of the Interphase Nucleus.

ABSTRACT: Condensins are conserved multi-subunit protein complexes that participate in eukaryotic genome organization. Well known for their role in mitotic chromosome condensation, condensins have recently emerged as integral components of diverse interphase processes. Recent evidence shows that condensins are involved in chromatin organization, gene expression, and DNA repair and indicates similarities between the interphase and mitotic functions of condensin. Recent work has enhanced our knowledge of how chromatin architecture is dynamically regulated by condensin to impact essential cellular processes.

SUBMITTER: Wallace HA

PROVIDER: S-EPMC3927828 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature

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Condensins and 3D Organization of the Interphase Nucleus.

Wallace Heather A HA Bosco Giovanni G

Current genetic medicine reports 20131201 4

Condensins are conserved multi-subunit protein complexes that participate in eukaryotic genome organization. Well known for their role in mitotic chromosome condensation, condensins have recently emerged as integral components of diverse interphase processes. Recent evidence shows that condensins are involved in chromatin organization, gene expression, and DNA repair and indicates similarities between the interphase and mitotic functions of condensin. Recent work has enhanced our knowledge of ho ...[more]

PMID: 24563825

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