Ontology highlight
ABSTRACT:
SUBMITTER: Katoh H
PROVIDER: S-EPMC3928012 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Cancer cell 20131101 5
A large body of evidence indicates that chronic inflammation is one of several key risk factors for cancer initiation, progression, and metastasis. However, the underlying mechanisms responsible for the contribution of inflammation and inflammatory mediators to cancer remain elusive. Here, we present genetic evidence that loss of CXCR2 dramatically suppresses chronic colonic inflammation and colitis-associated tumorigenesis through inhibiting infiltration of myeloid-derived suppressor cells (MDS ...[more]