Ontology highlight
ABSTRACT:
SUBMITTER: Ibrahim ML
PROVIDER: S-EPMC6319669 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Ibrahim Mohammed L ML Klement John D JD Lu Chunwan C Redd Priscilla S PS Xiao Wei W Yang Dafeng D Browning Darren D DD Savage Natasha M NM Buckhaults Phillip J PJ Morse Herbert C HC Liu Kebin K
Cell reports 20181201 11
IL-10 functions as a suppressor of colitis and colitis-associated colon cancer, but it is also a risk locus associated with ulcerative colitis. The mechanism underlying the contrasting roles of IL-10 in inflammation and colon cancer is unknown. We report here that inflammation induces the accumulation of CD11b<sup>+</sup>Gr1<sup>+</sup> myeloid-derived suppressor cells (MDSCs) that express high levels of IL-10 in colon tissue. IL-10 induces the activation of STAT3 that directly binds to the Dnmt ...[more]