Amorphous alumina nanowire array efficiently delivers Ac-DEVD-CHO to inhibit apoptosis of dendritic cells.
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ABSTRACT:
SUBMITTER: Lampert L
PROVIDER: S-EPMC3929101 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
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Amorphous alumina nanowire array efficiently delivers Ac-DEVD-CHO to inhibit apoptosis of dendritic cells.
Lampert Lester L Timonen Brittany B Smith Sean S Davidge Brittney B Li Haiyan H Conley John F JF Singer Jeffrey D JD Jiao Jun J
Chemical communications (Cambridge, England) 20140201 10
To create an effective well-ordered delivery platform still remains a challenge. Herein we fabricate vertically aligned alumina nanowire arrays via atomic layer deposition templated by carbon nanotubes. Using these arrays, a caspase-3/7 inhibitor was delivered into DC 2.4 cells and blocked apoptosis, as confirmed by fluorescence microscopy. ...[more]
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