Ontology highlight
ABSTRACT:
SUBMITTER: Manzanares D
PROVIDER: S-EPMC7731237 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Manzanares Darío D Pérez-Carrión María Dolores MD Jiménez Blanco José Luis JL Ortiz Mellet Carmen C García Fernández José Manuel JM Ceña Valentín V
International journal of molecular sciences 20201206 23
Small interfering ribonucleic acid (siRNA) has the potential to revolutionize therapeutics since it can knockdown very efficiently the target protein. It is starting to be widely used to interfere with cell infection by HIV. However, naked siRNAs are unable to get into the cell, requiring the use of carriers to protect them from degradation and transporting them across the cell membrane. There is no information about which is the most efficient endocytosis route for high siRNA transfection effic ...[more]