Ontology highlight
ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC3929229 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Wang Liangjing L Gala Manish M Yamamoto Masayoshi M Pino Maria S MS Kikuchi Hirotoshi H Shue Daniel S DS Shirasawa Senji S Austin Thomas R TR Lynch Maureen P MP Rueda Bo R BR Zukerberg Lawrence R LR Chung Daniel C DC
International journal of cancer 20131107 9
The KRAS oncogene influences angiogenesis, metastasis and chemoresistance in colorectal cancers (CRCs), and these processes are all enhanced in hypoxic conditions. To define functional activities of mutant KRAS in a hypoxic microenvironment, we first performed cDNA microarray experiments in isogenic DKs5 and DKO3 colon cancer cell lines that differ only by their expression of mutant KRAS (K-ras(D13)). Adrenomedullin (ADM) was identified as one of the most significantly upregulated genes in DKs5 ...[more]