Unknown

Dataset Information

0

Prevention of peritoneal adhesions using polymeric rheological blends.


ABSTRACT: The effectiveness of rheological blends of high molecular weight hyaluronic acid (HA) and low molecular weight hydroxypropyl methylcellulose (HPMC) in the prevention of peritoneal adhesions post-surgery is demonstrated. The physical mixture of the two carbohydrates increased the dwell time in the peritoneum while significantly improving the injectability of the polymer compared with HA alone. HA-HPMC treatment decreased the total adhesion area by ? 70% relative to a saline control or no treatment in a repeated cecal injury model in the rabbit. No significant cytotoxicity and minimal inflammation were associated with the blend. Furthermore, no chemical or physical processing was required prior to their use beyond simple mixing.

SUBMITTER: Hoare T 

PROVIDER: S-EPMC3929525 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

Prevention of peritoneal adhesions using polymeric rheological blends.

Hoare Todd T   Yeo Yoon Y   Bellas Evangelia E   Bruggeman Joost P JP   Kohane Daniel S DS  

Acta biomaterialia 20131221 3


The effectiveness of rheological blends of high molecular weight hyaluronic acid (HA) and low molecular weight hydroxypropyl methylcellulose (HPMC) in the prevention of peritoneal adhesions post-surgery is demonstrated. The physical mixture of the two carbohydrates increased the dwell time in the peritoneum while significantly improving the injectability of the polymer compared with HA alone. HA-HPMC treatment decreased the total adhesion area by ∼ 70% relative to a saline control or no treatmen  ...[more]

Similar Datasets

| S-EPMC11307292 | biostudies-literature
| S-EPMC7563493 | biostudies-literature
| S-EPMC7864184 | biostudies-literature
| S-EPMC8896906 | biostudies-literature
| S-EPMC7331037 | biostudies-literature
| S-EPMC8398677 | biostudies-literature
| S-EPMC8046819 | biostudies-literature
| S-EPMC7144390 | biostudies-literature
| S-EPMC8125886 | biostudies-literature
| S-EPMC8677808 | biostudies-literature