An epigenetic trap stabilizes singular olfactory receptor expression.
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ABSTRACT:
SUBMITTER: Lyons DB
PROVIDER: S-EPMC3929589 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Publications
An epigenetic trap stabilizes singular olfactory receptor expression.
Lyons David B DB Allen William E WE Goh Tracie T Tsai Lulu L Barnea Gilad G Lomvardas Stavros S
Cell 20130701 2
The molecular mechanisms regulating olfactory receptor (OR) expression in the mammalian nose are not yet understood. Here, we identify the transient expression of histone demethylase LSD1 and the OR-dependent expression of adenylyl cyclase 3 (Adcy3) as requirements for initiation and stabilization of OR expression. As a transcriptional coactivator, LSD1 is necessary for desilencing and initiating OR transcription, but as a transcriptional corepressor, it is incompatible with maintenance of OR ex ...[more]
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