Enhancer interaction networks as a means for singular olfactory receptor expression.
Ontology highlight
ABSTRACT:
SUBMITTER: Markenscoff-Papadimitriou E
PROVIDER: S-EPMC4243057 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Publications
Enhancer interaction networks as a means for singular olfactory receptor expression.
Markenscoff-Papadimitriou Eirene E Allen William E WE Colquitt Bradley M BM Goh Tracie T Murphy Karl K KK Monahan Kevin K Mosley Colleen P CP Ahituv Nadav N Lomvardas Stavros S
Cell 20141001 3
The transcriptional activation of one out of ?2800 olfactory receptor (OR) alleles is a poorly understood process. Here, we identify a plethora of putative OR enhancers and study their in vivo activity in olfactory neurons. Distinguished by an unusual epigenetic signature, candidate OR enhancers are characterized by extensive interchromosomal interactions associated with OR transcription and share a similar pattern of transcription factor footprints. In particular, we establish the role of the t ...[more]
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