Ontology highlight
ABSTRACT:
SUBMITTER: Scheel C
PROVIDER: S-EPMC3930331 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Scheel Christina C Eaton Elinor Ng EN Li Sophia Hsin-Jung SH Chaffer Christine L CL Reinhardt Ferenc F Kah Kong-Jie KJ Bell George G Guo Wenjun W Rubin Jeffrey J Richardson Andrea L AL Weinberg Robert A RA
Cell 20110601 6
The epithelial-mesenchymal transition (EMT) has been associated with the acquisition of motility, invasiveness, and self-renewal traits. During both normal development and tumor pathogenesis, this change in cell phenotype is induced by contextual signals that epithelial cells receive from their microenvironment. The signals that are responsible for inducing an EMT and maintaining the resulting cellular state have been unclear. We describe three signaling pathways, involving transforming growth f ...[more]