Ontology highlight
ABSTRACT:
SUBMITTER: Ullah G
PROVIDER: S-EPMC3930476 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Ullah Ghanim G Bruno William J WJ Pearson John E JE
Journal of theoretical biology 20120720
We present a practical method for simplifying Markov chains on a potentially large state space when detailed balance holds. A simple and transparent technique is introduced to remove states with low equilibrium occupancy. The resulting system has fewer parameters. The resulting effective rates between the remaining nodes give dynamics identical to the original system's except on very fast timescales. This procedure amounts to using separation of timescales to neglect small capacitance nodes in a ...[more]