Ontology highlight
ABSTRACT:
SUBMITTER: Hughan SC
PROVIDER: S-EPMC3931064 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Hughan Sascha C SC Spring Christopher M CM Schoenwaelder Simone M SM Sturgeon Sharelle S Alwis Imala I Yuan Yuping Y McFadyen James D JD Westein Erik E Goddard Duncan D Ono Akiko A Yamanashi Yuji Y Nesbitt Warwick S WS Jackson Shaun P SP
The Journal of biological chemistry 20140102 8
The Dok proteins are a family of adaptor molecules that have a well defined role in regulating cellular migration, immune responses, and tumor progression. Previous studies have demonstrated that Doks-1 to 3 are expressed in platelets and that Dok-2 is tyrosine-phosphorylated downstream of integrin αIIbβ3, raising the possibility that it participates in integrin αIIbβ3 outside-in signaling. We demonstrate that Dok-2 in platelets is primarily phosphorylated by Lyn kinase. Moreover, deficiency of ...[more]