Ontology highlight
ABSTRACT:
SUBMITTER: Sauer AK
PROVIDER: S-EPMC3931807 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Sauer Anne-Kathrin AK Liang Chi-Hui CH Stech Jürgen J Peeters Ben B Quéré Pascale P Schwegmann-Wessels Christel C Wu Chung-Yi CY Wong Chi-Huey CH Herrler Georg G
PloS one 20140221 2
Binding of influenza viruses to target cells is mediated by the viral surface protein hemagglutinin. To determine the presence of binding sites for influenza A viruses on cells and tissues, soluble hemagglutinins of the H7 and H9 subtype were generated by connecting the hemagglutinin ectodomain to the Fc portion of human immunoglobulin G (H7Fc and H9Fc). Both chimeric proteins bound to different cells and tissues in a sialic acid-dependent manner. Pronounced differences were observed between H7F ...[more]