Ontology highlight
ABSTRACT:
SUBMITTER: Blanchfield K
PROVIDER: S-EPMC4262278 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Blanchfield Kristy K Kamal Ram P RP Tzeng Wen-Pin WP Music Nedzad N Wilson Jason R JR Stevens James J Lipatov Aleksander S AS Katz Jacqueline M JM York Ian A IA
Influenza and other respiratory viruses 20140912 6
<h4>Background</h4>Vaccines against avian influenza viruses often require high hemagglutinin (HA) doses or adjuvants to achieve serological titers associated with protection against disease. In particular, viruses of the H7 subtype frequently do not induce strong antibody responses following immunization.<h4>Objectives</h4>To evaluate whether poor immunogenicity of H7 viruses is an intrinsic property of the H7 hemagglutinin.<h4>Methods</h4>We compared the immunogenicity, in naïve mice, of purifi ...[more]